Particle radiation therapy in the management of malignant glioma: Early experience at the Shanghai Proton and Heavy Ion Center.

ABSTRACT:

Background

The objective of this study was to evaluate the outcomes of patients with high-grade glioma who received treatment with particle radiotherapy.

Methods

Between June 2015 and October 2018, 50 consecutive and nonselected patients with glioblastoma multiforme (n = 34) or anaplastic glioma (n = 16) were treated at the Shanghai Proton and Heavy Ion Center. Twenty-four patients received proton radiotherapy (at a dose of 60 gray-equivalents in 30 daily fractions), and 26 patients received proton radiotherapy plus a carbon-ion radiotherapy (CIRT) boost in various dose-escalating schemes. All patients received temozolomide because of their age or their O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status. Progression-free survival (PFS) and overall sur

SUBMITTER: Kong L 

PROVIDER: S-EPMC7317504 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature