Trajectories of BMI Before Diagnosis of Type 2 Diabetes: The Rotterdam Study.

ABSTRACT: OBJECTIVE:People with diabetes show great variability in weight gain and duration of obesity at the time of diagnosis. BMI trajectories and other cardiometabolic risk factors prior to type 2 diabetes were investigated. METHODS:A total of 6,223 participants from the Rotterdam Study cohort were included. BMI patterns before diagnosis of diabetes were identified through latent class trajectories. RESULTS:During a mean follow-up of 13.7 years, 565 participants developed type 2 diabetes. Three distinct trajectories of BMI were identified, including the "progressive overweight" group (n = 481, 85.1%), "progressive weight loss" group (n = 59, 10.4%), and "persistently high BMI" group (n = 25, 4.4%). The majority, the progressive overweight group, was characterized by a steady increase of BMI in t

SUBMITTER: Nano J 

PROVIDER: S-EPMC7317538 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature