Liver-related long-term outcomes of thiazolidinedione use in persons with type 2 diabetes.

ABSTRACT:

Background & aims

Studies have described prominent histologic improvement in patients with nonalcoholic steatohepatitis (NASH) using thiazolidinedione (TZD); however, these were all short term with moderate sample size, no liver-related long-term outcomes could be noted.

Methods

This retrospective cohort study enrolled patients with newly diagnosed type 2 diabetes mellitus (T2DM) from Taiwan's National Health Insurance Research Database between 1 January 2000 and 31 December 2013. We matched TZD users and nonusers at a 1:1 ratio through propensity score matching. This study included 5095 paired TZD users and nonusers. Cox proportional hazard models were used to compare the risks of cirrhosis, hepatic decompensation, hepatic failure and all-cause mortality between TZD users a

SUBMITTER: Yen FS 

PROVIDER: S-EPMC7317545 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature