Out-of-home care in childhood and biomedical risk factors in middle-age: National birth cohort study.

ABSTRACT:

Objective

With there being an apparent impact of experience of out-of-home care in childhood on chronic disease and mortality, we examined how such adversity might be embodied such that it has a measurable impact on human biology, so mediating this relationship.

Methods

We used data from the UK National Child Development Study in which exposure to public care was prospectively gathered on three occasions up to age 16. Study members also participated in a social survey at age 42 and a clinical examination at age 44/45 when cardiovascular, inflammatory, neuroendocrine, and respiratory risk markers for mortality were collected, 19 of which were included as endpoints in the present analyses.

Results

Of the 8012 participants in the biomedical survey, 4% (n = 322) had been

SUBMITTER: de Mestral C 

PROVIDER: S-EPMC7317568 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature