Testing of acetaminophen in support of the international multilaboratory in vivo rat Pig-a assay validation trial.

ABSTRACT: Acetaminophen, a nonmutagenic compound as previously concluded from bacteria, in vitro mammalian cell, and in vivo transgenic rat assays, presented a good profile as a nonmutagenic reference compound for use in the international multilaboratory Pig-a assay validation. Acetaminophen was administered at 250, 500, 1,000, and 2,000 mg·kg^-1 ·day^-1 to male Sprague Dawley rats once daily in 3 studies (3 days, 2 weeks, and 1 month with a 1-month recovery group). The 3-Day and 1-Month Studies included assessments of the micronucleus endpoint in peripheral blood erythrocytes and the comet endpoint in liver cells and peripheral blood cells in addition to the Pig-a assay; appropriate positive controls were included for each assay. Within these studies, potential toxicity of aceta

SUBMITTER: van der Leede BJ 

PROVIDER: S-EPMC7317746 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature