Anti-platelet antibody immunoassays in childhood immune thrombocytopenia: a systematic review.

ABSTRACT:

Background

In adult immune thrombocytopenia (ITP), an acquired autoimmune bleeding disorder, anti-platelet autoantibody testing may be useful as a rule-in test. Childhood ITP has different disease characteristics, and the diagnostic and prognostic value of anti-platelet antibody testing remains uncertain.

Objective

To systematically review the diagnostic accuracy of anti-platelet autoantibody testing in childhood ITP.

Methods

PubMed and EMBASE were searched for studies evaluating immunoassays in childhood ITP. Study quality was assessed (QUADAS2), and evidence was synthesized descriptively.

Results

In total, 40 studies (1606 patients) were identified. Nine studies reported sufficient data to determine diagnostic accuracy measures. Anti-platelet IgG antibody tes

SUBMITTER: Schmidt DE 

PROVIDER: S-EPMC7317748 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature