Involvement of the epidermal growth factor receptor in IL-13-mediated corticosteroid-resistant airway inflammation.

ABSTRACT:

Background

Effective treatment for severe asthma is a significant unmet need. While eosinophilic inflammation caused by type 2 cytokines is responsive to corticosteroid and biologic therapies, many severe asthmatics exhibit corticosteroid-unresponsive mixed granulocytic inflammation.

Objective

Here, we tested the hypothesis that the pro-allergic cytokine, IL-13, can drive both corticosteroid-sensitive and corticosteroid-resistant responses.

Results

By integration of in vivo and in vitro models of IL-13-driven inflammation, we identify a role for the epidermal growth factor receptor (EGFR/ERBB1) as a mediator of corticosteroid-unresponsive inflammation and bronchial hyperresponsiveness driven by IL-13. Topological data analysis using human epithelial transcriptomic dat

SUBMITTER: Davies ER 

PROVIDER: S-EPMC7317751 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature