Prenatal sonographic features can accurately determine parental origin in triploid pregnancies.

ABSTRACT:

Objective

To describe the prenatal sonographic features and maternal biochemical markers in triploid pregnancies and to assess whether prenatal phenotype can determine genetic origin.

Methods

We performed a retrospective multicenter cohort study that included all triploid pregnancies diagnosed between 2000 and 2018 in two Fetal Medicine Units in Amsterdam. Fetal growth, presence of structural anomalies, extra-fetal anomalies, and maternal biochemical markers were retrieved. Asymmetrical intrauterine growth restriction was diagnosed when the head-to-abdominal circumference (HC/AC) ratio was >95th centile. Parental origin was analyzed via molecular genotyping in 46 cases (38.3%).

Results

One hundred and twenty triploid pregnancies were identified, of which 86 cases (71.

SUBMITTER: Lugthart MA 

PROVIDER: S-EPMC7317806 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature