Reducing the burden of hypoglycaemia in people with diabetes through increased understanding: design of the Hypoglycaemia REdefining SOLutions for better liVEs (Hypo-RESOLVE) project.

ABSTRACT:

Background

Hypoglycaemia is the most frequent complication of treatment with insulin or insulin secretagogues in people with diabetes. Severe hypoglycaemia, i.e. an event requiring external help because of cognitive dysfunction, is associated with a higher risk of adverse cardiovascular outcomes and all-cause mortality, but underlying mechanism(s) are poorly understood. There is also a gap in the understanding of the clinical, psychological and health economic impact of 'non-severe' hypoglycaemia and the glucose level below which hypoglycaemia causes harm.

Aim

To increase understanding of hypoglycaemia by addressing the above issues over a 4-year period.

Methods

Hypo-RESOLVE is structured across eight work packages, each with a distinct focus. We will construct a larg

SUBMITTER: de Galan BE 

PROVIDER: S-EPMC7317819 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature