External validation and clinical utility of prognostic prediction models for gestational diabetes mellitus: A prospective cohort study.

ABSTRACT: INTRODUCTION:We performed an independent validation study of all published first trimester prediction models, containing non-invasive predictors, for the risk of gestational diabetes mellitus. Furthermore, the clinical potential of the best performing models was evaluated. MATERIAL AND METHODS:Systemically selected prediction models from the literature were validated in a Dutch prospective cohort using data from Expect Study I and PRIDE Study. The predictive performance of the models was evaluated by discrimination and calibration. Clinical utility was assessed using decision curve analysis. Screening performance measures were calculated at different risk thresholds for the best model and compared with current selective screening strategies. RESULTS:The validation cohort included 5260 wome

SUBMITTER: Meertens LJE 

PROVIDER: S-EPMC7317858 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature