SWI/SNF chromatin remodeling complex and glucose metabolism are deregulated in advanced bladder cancer.

ABSTRACT: Bladder cancer (BC) is a frequently diagnosed malignancy affecting predominantly adult and elderly populations. It is expected that due to the longer life time, BC will become even more frequent in the future; thus in consequence, it will represent serious health problem of older society part. The treatment of advanced BC is mostly ineffective due to its very aggressive behavior. So far, no effective targeted therapy is used for BC treatment. Here, we found that BC is characterized by lower protein levels of BRM, INI1, and BAF155 main subunits of SWI/SNF chromatin remodeling complex (CRC) which is involved in global control of gene expression and influences various important cellular processes like: cell cycle control, apoptosis, DNA repair, etc. Moreover, the expression of SMARCA2, a BRM

SUBMITTER: Stachowiak M 

PROVIDER: S-EPMC7317882 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature