Control of Akt activity and substrate phosphorylation in cells.

ABSTRACT: Protein kinase B/Akt is a serine/threonine kinase that links receptors coupled to the PI3K lipid kinase to cellular anabolic pathways. Its activity in cells is controlled by reversible phosphorylation and an intramolecular lipid-controlled allosteric switch. In this review, I outline the current progress in understanding Akt regulatory mechanisms, define three models of Akt activation in cells, and highlight how intramolecular allosterism cooperates with cell-autonomous mechanisms to control Akt localization and activity and direct it toward specific sets of substrates in cells.

SUBMITTER: Yudushkin I 

PROVIDER: S-EPMC7317883 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature