Relationship between cardiorespiratory phase coherence during hypoxia and genetic polymorphism in humans.

ABSTRACT:

Key points

High altitude-induced hypoxia in humans evokes a pattern of breathing known as periodic breathing (PB), in which the regular oscillations corresponding to rhythmic expiration and inspiration are modulated by slow periodic oscillations. The phase coherence between instantaneous heart rate and respiration is shown to increase significantly at the frequency of periodic breathing during acute and sustained normobaric and hypobaric hypoxia. It is also shown that polymorphism in specific genes, NOTCH4 and CAT, is significantly correlated with this coherence, and thus with the incidence of PB. Differences in phase shifts between blood flow signals and respiratory and PB oscillations clearly demonstrate contrasting origins of the mechanisms underlying normal respiration and PB.

SUBMITTER: Lancaster G 

PROVIDER: S-EPMC7317918 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature