Reduction in the neuronal surface of post and presynaptic GABA_B receptors in the hippocampus in a mouse model of Alzheimer's disease.

ABSTRACT: The hippocampus plays key roles in learning and memory and is a main target of Alzheimer's disease (AD), which causes progressive memory impairments. Despite numerous investigations about the processes required for the normal hippocampal functions, the neurotransmitter receptors involved in the synaptic deficits by which AD disables the hippocampus are not yet characterized. By combining histoblots, western blots, immunohistochemistry and high-resolution immunoelectron microscopic methods for GABA_B receptors, this study provides a quantitative description of the expression and the subcellular localization of GABA_B1 in the hippocampus in a mouse model of AD at 1, 6 and 12 months of age. Western blots and histoblots showed that the total amount of protein and the lamina

SUBMITTER: Martin-Belmonte A 

PROVIDER: S-EPMC7317930 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature