Induction of IgG₂ and IgG₄ B-cell memory following sublingual immunotherapy for ryegrass pollen allergy.

ABSTRACT:

Background

While treatment for atopic rhinitis is aimed mostly to relieve symptoms, only allergen-specific immunotherapy (AIT) is targeted to modify the natural history of allergic diseases. This results in sustained clinical tolerance, even when treatment has stopped. The immunomodulatory effects of AIT are attributed mainly to increased regulatory T-cell function and increased allergen-specific IgG₄ , yet little is known about the effect on the memory B-cell compartment.

Objective

We aimed to examine the effects of AIT on the IgE- and IgG subclass-expressing memory B cells.

Methods

We recruited 29 patients with atopic seasonal rhinoconjunctivitis and performed a longitudinal analysis of the peripheral immune compartment before, during, and after sublingua

SUBMITTER: Heeringa JJ 

PROVIDER: S-EPMC7317934 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature