Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.

ABSTRACT:

Objective

The present work evaluates the relationship between postoperative immune and neurovascular changes and the pathogenesis of surgery-induced delirium superimposed on dementia.

Background and rationale

Postoperative delirium is a common complication in many older adults and in patients with dementia including Alzheimer's disease (AD). The course of delirium can be particularly debilitating, while its pathophysiology remains poorly defined.

Historical evolution

As of 2019, an estimated 5.8 million people of all ages have been diagnosed with AD, 97% of whom are >65 years of age. Each year, many of these patients require surgery. However, anesthesia and surgery can increase the risk for further cognitive decline. Surgery triggers neuroinflammation both in animal m

SUBMITTER: Wang P 

PROVIDER: S-EPMC7317948 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature