Transplantation of iPS-derived vascular endothelial cells improves white matter ischemic damage.

ABSTRACT: White matter infarct induces demyelination and brain dysfunction. We previously reported that transplantation of brain microvascular endothelial cells improved the behavioral outcome and promoted remyelination by increasing the number of oligodendrocyte precursor cells in the rat model of white matter infarct. In this study, we investigated the effects of transplantation of vascular endothelial cells generated from human induced pluripotent stem cells (iPSCs) on the rat model of white matter infarct. Seven days after induction of ischemic demyelinating lesion by injection of endothelin-1 into the internal capsule of a rat brain, iPSC-derived vascular endothelial cells (iVECs) were transplanted into the site of demyelination. The majority of iVECs transplanted into the internal capsule surv

SUBMITTER: Xu B 

PROVIDER: S-EPMC7317957 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature