Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages.

ABSTRACT: Earlier genetic and inhibitor studies showed that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new antimalarials. We therefore evaluated the activity of 350 diverse epigenetic inhibitors against multiple stages of Plasmodium falciparum We observed ≥90% inhibition at 10 μM for 28% of compounds against asexual blood stages and early gametocytes, of which a third retained ≥90% inhibition at 1 μM.

SUBMITTER: Vanheer LN 

PROVIDER: S-EPMC7318029 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature