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Circuit Topology Analysis of Polymer Folding Reactions.


ABSTRACT: Circuit topology is emerging as a versatile measure to classify the internal structures of folded linear polymers such as proteins and nucleic acids. The topology framework can be applied to a wide range of problems, most notably molecular folding reactions that are central to biology and molecular engineering. In this Outlook, we discuss the state-of-the art of the technology and elaborate on the opportunities and challenges that lie ahead.

SUBMITTER: Heidari M 

PROVIDER: S-EPMC7318069 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Circuit Topology Analysis of Polymer Folding Reactions.

Heidari Maziar M   Schiessel Helmut H   Mashaghi Alireza A  

ACS central science 20200512 6


Circuit topology is emerging as a versatile measure to classify the internal structures of folded linear polymers such as proteins and nucleic acids. The topology framework can be applied to a wide range of problems, most notably molecular folding reactions that are central to biology and molecular engineering. In this Outlook, we discuss the state-of-the art of the technology and elaborate on the opportunities and challenges that lie ahead. ...[more]

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