Early life metal dysregulation in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

Deficiencies and excess of essential elements and toxic metals are implicated in amyotrophic lateral sclerosis (ALS), but the age when metal dysregulation appears remains unknown. This study aims to determine whether metal uptake is dysregulated during childhood in individuals eventually diagnosed with ALS.

Methods

Laser ablation-inductively coupled plasma-mass spectrometry was used to obtain time series data of metal uptake using biomarkers in teeth from autopsies or dental extractions of ALS (n = 36) and control (n = 31) participants. Covariate data included sex, smoking, occupational exposures, and ALS family history. Case-control differences were identified in temporal profiles of metal uptake for individual metals using distributed lag models. Weighted quantil

SUBMITTER: Figueroa-Romero C 

PROVIDER: S-EPMC7318091 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature