Intracellular ATP levels influence cell fates in Dictyostelium discoideum differentiation.

ABSTRACT: Multicellular organisms contain various differentiated cells. Fate determination of these cells remains a fundamental issue. The cellular slime mold Dictyostelium discoideum is a useful model organism for studying differentiation; it proliferates as single cells in nutrient-rich conditions, which aggregate into a multicellular body upon starvation, subsequently differentiating into stalk cells or spores. The fates of these cells can be predicted in the vegetative phase: Cells expressing higher and lower levels of omt12 differentiate into stalk cells and spores, respectively. However, omt12 is merely a marker gene and changes in its expression do not influence the cell fate, and determinant factors remain unknown. In this study, we analyzed cell fate determinants in the stalk-destined and s

SUBMITTER: Hiraoka H 

PROVIDER: S-EPMC7318147 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature