Anti-platelet antibodies in childhood immune thrombocytopenia: Prevalence and prognostic implications.

ABSTRACT:

Background

Anti-platelet antibody testing may be useful for the diagnosis and management of childhood immune thrombocytopenia (ITP).

Objectives

Here we aimed to assess the prevalence and prognostic significance of anti-platelet glycoprotein-specific IgM and IgG antibodies.

Methods

Children with newly diagnosed ITP were included at diagnosis and randomized to an intravenous immunoglobulins (IVIg) or careful observation group (TIKI trial). In this well-defined and longitudinally followed cohort (N = 179), anti-platelet glycoprotein-specific IgM and IgG antibodies were determined by monoclonal antibody-immobilization of platelet antigens.

Results

The dominant circulating anti-platelet antibody class in childhood ITP was IgM (62% of patients); but IgG antibodies we

SUBMITTER: Schmidt DE 

PROVIDER: S-EPMC7318215 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature