Surface Design for Immobilization of an Antimicrobial Peptide Mimic for Efficient Anti-Biofouling.

ABSTRACT: Microbial surface attachment negatively impacts a wide range of devices from water purification membranes to biomedical implants. Mimics of antimicrobial peptides (AMPs) constituted from poly(N-substituted glycine) "peptoids" are of great interest as they resist proteolysis and can inhibit a wide spectrum of microbes. We investigate how terminal modification of a peptoid AMP-mimic and its surface immobilization affect antimicrobial activity. We also demonstrate a convenient surface modification strategy for enabling alkyne-azide "click" coupling on amino-functionalized surfaces. Our results verified that the N- and C-terminal peptoid structures are not required for antimicrobial activity. Moreover, our peptoid immobilization density and choice of PEG tether resulted in a "volumetric" spati

SUBMITTER: Hasan A 

PROVIDER: S-EPMC7318250 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature