Nicotine delivery and users' reactions to Juul compared with cigarettes and other e-cigarette products.

ABSTRACT:

Aims

To assess the pharmacokinetic (PK) profile of, and users' reactions to, Juul (59 mg nicotine/ml) as an indication of its therapeutic and dependence potential.

Design

Cross-over, within-subjects study in which participants attended after overnight abstinence on separate sessions and smoked a cigarette or used Juul or eight other types of e-cigarettes (EC) ad libitum for 5 minutes. The Juul product used was the version available in the United States that has more nicotine in the e-liquid than the one available in the European Union.

Setting

Laboratory setting in the United Kingdom.

Participants

Twenty dual users (smokers who also vape) provided data on Juul and cigarettes, with eight also providing data on other EC products.

Measurements

At each sessi

SUBMITTER: Hajek P 

PROVIDER: S-EPMC7318270 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature