Effectiveness by gender and age of renin-angiotensin system blockade in heart failure-A national register-based cohort study.

ABSTRACT:

Purpose

Investigate effectiveness by gender and age and equity implications of treatment with renin-angiotensin system blockade (RASb) in heart failure (HF) patients.

Methods

In this population-based register study, we used inpatient data from 2006 to 2010 for patients age 20 years or older with no HF hospitalisation for minimum of 1 year before an index hospitalisation. A wash-out period for RASb of 6 months preceding admission was used. Hospital data were linked with drug dispensation data and cause of death data. The associations between time-dependent RASb exposure and all-cause death and HF death, respectively, were examined by Cox regression models. Interactions by gender and age were also investigated on the multiplicative and additive scales.

Results

Thirty th

SUBMITTER: Ohlsson A 

PROVIDER: S-EPMC7318275 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature