Observational versus antibiotic treatment for uncomplicated diverticulitis: an individual-patient data meta-analysis.

ABSTRACT:

Background

Two RCTs (AVOD and DIABOLO) demonstrated no difference in recovery or adverse outcomes when antibiotics for acute uncomplicated diverticulitis were omitted. Both trials showed non-significantly higher rates of complicated diverticulitis and surgery in the non-antibiotic groups. This meta-analysis of individual-patient data aimed to explore adverse outcomes and identify patients at risk who may benefit from antibiotic treatment.

Methods

Individual-patient data from those with uncomplicated diverticulitis from two RCTs were pooled. Risk factors for adverse outcomes and the effect of observational management were assessed using logistic regression analyses. P < 0·025 was considered statistically significant owing to multiple testing adjustment.

Results

In tota

SUBMITTER: van Dijk ST 

PROVIDER: S-EPMC7318319 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature