Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis.

ABSTRACT: BACKGROUND:Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD) characterised by liver fat accumulation, inflammation and progressive fibrosis. Emerging data indicate that genetic susceptibility increases risks of NAFLD, NASH and NASH-related cirrhosis. AIMS:To review NASH genetics and discuss the potential for precision medicine approaches to treatment. METHOD:PubMed search and inclusion of relevant literature. RESULTS:Single-nucleotide polymorphisms in PNPLA3, TM6SF2, GCKR, MBOAT7 and HSD17B13 are clearly associated with NASH development or progression. These genetic variants are common and have moderate-to-large effect sizes for development of NAFLD, NASH and hepatocellular carcinoma (HCC). The genes play roles in lipid remodelling in lipid

SUBMITTER: Carlsson B 

PROVIDER: S-EPMC7318322 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature