A Microfluidic Co-Flow Route for Human Serum Albumin-Drug-Nanoparticle Assembly.

ABSTRACT: Nanoparticles are widely studied as carrier vehicles in biological systems because their size readily allows access through cellular membranes. Moreover, they have the potential to carry cargo molecules and as such, these factors make them especially attractive for intravenous drug delivery purposes. Interest in protein-based nanoparticles has recently gained attraction due to particle biocompatibility and lack of toxicity. However, the production of homogeneous protein nanoparticles with high encapsulation efficiencies, without the need for additional cross-linking or further engineering of the molecule, remains challenging. Herein, we present a microfluidic 3D co-flow device to generate human serum albumin/celastrol nanoparticles by co-flowing an aqueous protein solution with celastrol i

SUBMITTER: Hakala TA 

PROVIDER: S-EPMC7318336 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature