Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease.

ABSTRACT:

Background

Fatty liver is a high incidence of perinatal disease in dairy cows caused by negative energy balance, which seriously threatens the postpartum health and milk production. It has been reported that lysine acetylation plays an important role in substance and energy metabolism. Predictably, most metabolic processes in the liver, as a vital metabolic organ, are subjected to acetylation. Comparative acetylome study were used to quantify the hepatic tissues from the severe fatty liver group and normal group. Combined with bioinformatics analysis, this study provides new insights for the role of acetylation modification in fatty liver disease of dairy cows.

Results

We identified 1841 differential acetylation sites on 665 proteins. Among of them, 1072 sites on 393 protein

SUBMITTER: Le-Tian Z 

PROVIDER: S-EPMC7318365 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature