A novel method for interpreting survival analysis data: description and test on three major clinical trials on cardiovascular prevention.

ABSTRACT:

Background

Major results of randomized clinical trials on cardiovascular prevention are currently provided in terms of relative or absolute risk reductions, including also the number needed to treat (NNT), incorrectly implying that a treatment might prevent the occurrence of the outcome/s under investigation. Provided that these results are based on survival analysis, the primary measure of which is time-to-the outcome and not the outcome itself, we sought an alternative method to describe, analyse and interpret clinical trial results consistent with this assumption, so as to better define qualitative and quantitative heterogeneity of various therapeutic strategies in terms of their effects and costs.

Methods

The original Kaplan-Meier graphs of three major positive cardiovas

SUBMITTER: Mengozzi A 

PROVIDER: S-EPMC7318394 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature