Alternative splicing is highly variable among Daphnia pulex lineages in response to acute copper exposure.

ABSTRACT:

Background

Despite being one of the primary mechanisms of gene expression regulation in eukaryotes, alternative splicing is often overlooked in ecotoxicogenomic studies. The process of alternative splicing facilitates the production of multiple mRNA isoforms from a single gene thereby greatly increasing the diversity of the transcriptome and proteome. This process can be important in enabling the organism to cope with stressful conditions. Accurate identification of splice sites using RNA sequencing requires alignment to independent exonic positions within the genome, presenting bioinformatic challenges, particularly when using short read data. Although technological advances allow for the detection of splicing patterns on a genome-wide scale, very little is known about the extent

SUBMITTER: Suresh S 

PROVIDER: S-EPMC7318467 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature