Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer.

ABSTRACT:

Background

Unlike other breast cancer subtypes that may be treated with a variety of hormonal or targeted therapies, there is a need to identify new, effective targets for triple-negative breast cancer (TNBC). It has recently been recognized that membrane potential is depolarized in breast cancer cells. The primary objective of the study is to explore whether hyperpolarization induced by opening potassium channels may provide a new strategy for treatment of TNBC.

Methods

Breast cancer datasets in cBioPortal for cancer genomics was used to search for ion channel gene expression. Immunoblots and immunohistochemistry were used for protein expression in culture cells and in the patient tissues. Electrophysiological patch clamp techniques were used to study properties of BK chann

SUBMITTER: Sizemore G 

PROVIDER: S-EPMC7318490 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature