Tetracationic Bis-Triarylborane 1,3-Butadiyne as a Combined Fluorimetric and Raman Probe for Simultaneous and Selective Sensing of Various DNA, RNA, and Proteins.

ABSTRACT: A bis-triarylborane tetracation (4-Ar2 B-3,5-Me2 C6 H2 )-C≡C-C≡C-(3,5-Me2 C6 H2 -4-BAr2 [Ar=(2,6-Me2 -4-NMe3 -C6 H2 )+ ] (24+ ) shows distinctly different behaviour in its fluorimetric response than that of our recently published bis-triarylborane 5-(4-Ar2 B-3,5-Me2 C6 H2 )-2,2'-(C4 H2 S)2 -5'-(3,5-Me2 C6 H2 -4-BAr2 ) (34+ ). Single-crystal X-ray diffraction data on the neutral bis-triarylborane precursor 2 N confirm its rod-like dumbbell structure, which is shown to be important for DNA/RNA targeting and also for BSA protein binding. Fluorimetric titrations with DNA/RNA/BSA revealed the very strong affinity of 24+ and indicated the importance of the properties of the linker connecting the two triarylboranes. Using the butadiyne rather than a bithiophene linker resulted in an opposite emis

SUBMITTER: Amini H 

PROVIDER: S-EPMC7318631 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature