Therapeutic and prophylactic deletion of IL-4Ra-signaling ameliorates established ovalbumin induced allergic asthma.

ABSTRACT:

Background

Allergic asthma is a chronic inflammatory airway disease driven predominantly by a T_H 2 immune response to environmental allergens. IL-4Rα-signaling is essential for driving T_H 2-type immunity to allergens. Anti-T_H 2 therapies have the potential to effectively reduce airway obstruction and inflammation in allergic asthma.

Objective

We investigated potential therapeutic effects of selective inhibition of this pathway in mice with established allergic airway disease. We further investigated whether IL-4Rα disruption in systemically sensitized mice can prevent the onset of the disease.

Methods

We used Rosa^creERT2 IL-4Rα^-/lox mice, a tamoxifen (TAM)-inducible IL-4Rα knockdown model to investigate the role o

SUBMITTER: Khumalo J 

PROVIDER: S-EPMC7318634 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature