A pilot study of essential tremor: cerebellar GABA+/Glx ratio is correlated with tremor severity.

ABSTRACT:

Objective

Essential tremor is a common movement disorder with an unclear origin. Emerging evidence suggests the role of the cerebellum and the thalamus in tremor pathophysiology. We examined the two main neurotransmitters acting inhibitory (GABA+) and excitatory (Glx) respectively, in the thalamus and cerebellum, in patients diagnosed with severe essential tremor. Furthermore, we also investigated the relationship between determined neurotransmitter concentrations and tremor severity in the essential tremor patients.

Methods

Ten essential tremor patients (prior to deep brain stimulation surgery) and six healthy controls, were scanned using a 3 T MR system. GABA+ and Glx concentrations were measured using magnetic resonance spectroscopy (MRS) performed using single voxel MEGA

SUBMITTER: Tapper S 

PROVIDER: S-EPMC7318770 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature