Single-cell immune landscape of human atherosclerotic plaques.

ABSTRACT: Atherosclerosis is driven by multifaceted contributions of the immune system within the circulation and at vascular focal sites. However, specific characteristics of dysregulated immune cells within atherosclerotic lesions that lead to clinical events such as ischemic stroke or myocardial infarction are poorly understood. Here, using single-cell proteomic and transcriptomic analyses, we uncovered distinct features of both T cells and macrophages in carotid artery plaques of patients with clinically symptomatic disease (recent stroke or transient ischemic attack) compared to asymptomatic disease (no recent stroke). Plaques from symptomatic patients were characterized by a distinct subset of CD4⁺ T cells and by T cells that were activated and differentiated. Moreover, some T cell

SUBMITTER: Fernandez DM 

PROVIDER: S-EPMC7318784 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature