Carboplatin-based regimen in pediatric intracranial germ-cell tumors (IC-GCTs): effectiveness and ototoxicity.

ABSTRACT:

Background

Induction chemotherapy with carboplatin followed by radiotherapy has been used for many years for treating intracranial germ-cell tumors (IC-GCTs) in Thailand. The objective of this study was to assess treatment outcomes, focusing on survival and ototoxicity.

Methods

The outcomes of all patients with IC-GCT treated at Ramathibodi Hospital and the Prasat Neurological Institute between 2000 and 2017 were reviewed and analyzed, including all patient characteristics and treatment modalities. Five-year overall survival (OS) and event-free survival (EFS) were analyzed using the Kaplan-Meier method, and factors affecting survival were compared using the log-rank test.

Results

Fifty-three patients age 1-14 years (median, 11 years) were included in this study. The m

SUBMITTER: Worawongsakul R 

PROVIDER: S-EPMC7318857 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature