Influence of SLCO1B1 polymorphisms on lopinavir C_trough in Serbian HIV/AIDS patients.

ABSTRACT:

Aims

Lopinavir (LPV) is not a first-line regimen. According to recent WHO data, LPV usage in low- and middle-income countries accounted for approximately 52% of the adult and 23% of the paediatric protease inhibitor market in 2017. Since LPV is a substrate for the SLCO1B1 (OATP1B1) transporter, the aim of this study was to assess the impact of SLCO1B1 polymorphisms (rs11045819, rs4149032 and rs4149056) on LPV trough plasma concentrations (C_trough ) in Serbian patients.

Methods

Plasma samples from 104 HIV/AIDS Caucasians were collected. LPV C_trough was quantified using liquid-chromatography-mass spectrometry. Genotyping was carried out using real-time-PCR-based allelic discrimination. One-way analysis of variance, t test and linear regression were used f

SUBMITTER: Dragovic G 

PROVIDER: S-EPMC7319006 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature