Metamizole: An underrated agent causing severe idiosyncratic drug-induced liver injury.

ABSTRACT:

Aims

Drug-induced liver injury (DILI) is a heterogenous entity leading to liver damage. We have analysed the frequency, biochemical and histological patterns and clinical courses of DILI cases due to metamizole at our tertiary care centre in Hamburg, Germany.

Methods

Consecutive patients with DILI who presented to our clinic were analysed retrospectively. Causes of acute hepatitis other than DILI were excluded.

Results

In total, 154 DILI cases were admitted to our centre from 2008 to 2017. After phenprocoumon, metamizole was the second most frequent putative agent causing DILI (23 of all 154 DILI cases, 14,9%). The biochemical pattern on admission of metamizole-induced DILI cases was hepatocellular with median levels of alanine transaminase (779 U/L, 64-3532 U/L) by f

SUBMITTER: Sebode M 

PROVIDER: S-EPMC7319009 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature