Identification of a Potential Peptide Inhibitor of SARS-CoV-2 Targeting its Entry into the Host Cells.

ABSTRACT:

Background and objective

Coronavirus disease (COVID-19) is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the incessant spread of the disease with substantial morbidity and mortality rates, there is an urgent demand for effective therapeutics and vaccines to control and diminish this pandemic. A critical step in the crosstalk between the virus and the host cell is the binding of SARS-CoV-2 spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor present on the surface of the host cells. Hence, inhibition of this interaction could be a promising strategy to combat the SARS-CoV-2 infection.

Methods

Docking and Molecular Dynamics (MD) simulation studies revealed that designed peptide maintains their secondary struc

SUBMITTER: Baig MS 

PROVIDER: S-EPMC7319219 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature