A chronic rejection model and potential biomarkers for vascularized composite allotransplantation.

ABSTRACT:

Background

Chronic rejection remains the Achilles heel in vascularized composite allotransplantation. Animal models to specifically study chronic rejection in vascularized composite allotransplantation do not exist so far. However, there are established rat models to study chronic rejection in solid organ transplantation such as allogeneic transplantation between the rat strains Lewis and Fischer344. Thus, we initiated this study to investigate the applicability of hindlimb transplantation between these strains to imitate chronic rejection in vascularized composite allotransplantation and identify potential markers.

Methods

Allogeneic hindlimb transplantation were performed between Lewis (recipient) and Fischer344 (donor) rats with either constant immunosuppression or a high

SUBMITTER: Puscz F 

PROVIDER: S-EPMC7319338 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature