Maternal risk factors for the VACTERL association: A EUROCAT case-control study.

ABSTRACT:

Background

The VACTERL association (VACTERL) is the nonrandom occurrence of at least three of these congenital anomalies: vertebral, anal, cardiac, tracheoesophageal, renal, and limb anomalies. Despite suggestions for involvement of several genes and nongenetic risk factors from small studies, the etiology of VACTERL remains largely unknown.

Objective

To identify maternal risk factors for VACTERL in offspring in a large European study.

Methods

A case-control study was performed using data from 28 EUROCAT registries over the period 1997-2015 with case and control ascertainment through hospital records, birth and death certificates, questionnaires, and/or postmortem examinations. Cases were diagnosed with VACTERL, while controls had a genetic syndrome and/or chromosomal

SUBMITTER: van de Putte R 

PROVIDER: S-EPMC7319423 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature