RNAProbe: a web server for normalization and analysis of RNA structure probing data.

ABSTRACT: RNA molecules play key roles in all living cells. Knowledge of the structural characteristics of RNA molecules allows for a better understanding of the mechanisms of their action. RNA chemical probing allows us to study the susceptibility of nucleotides to chemical modification, and the information obtained can be used to guide secondary structure prediction. These experimental results can be analyzed using various computational tools, which, however, requires additional, tedious steps (e.g., further normalization of the reactivities and visualization of the results), for which there are no fully automated methods. Here, we introduce RNAProbe, a web server that facilitates normalization, analysis, and visualization of the low-pass SHAPE, DMS and CMCT probing results with the modification s

SUBMITTER: Wirecki TK 

PROVIDER: S-EPMC7319577 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature