Genotypic and allelic frequencies of MDR1 gene in dogs in Italy.

ABSTRACT:

Background

A mutation in the canine multidrug resistance MDR1 gene (also referred as ABCB1), encoding for the multidrug resistance (MDR) P-glycoprotein (P-gp) transponder, causes a pathological condition known as 'ivermectin toxicosis'. The causative mutation, known since 2001, has been described to affects sheep herding breeds related to collie lineage. The present study is a retrospective investigation of the presence of MDR1 mutated allele in Italian dog populations in a 5 years' time lapse. The aim of the research is to offer a deep knowledge in MDR1 allelic and genotypic frequencies in canine breeds and populations raised in Italy.

Methods

Genotype data for the 4-bp deletion (c296_299del4) in MDR1 gene from 811 dogs belonging to

SUBMITTER: Marelli SP 

PROVIDER: S-EPMC7319724 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature