Multistrain Probiotic Increases the Gut Microbiota Diversity in Obese Pregnant Women: Results from a Randomized, Double-Blind Placebo-Controlled Study.

ABSTRACT:

Background

Maternal obesity is associated with adverse pregnancy outcomes. Probiotic supplementation during pregnancy may have positive effects on blood glucose, gestational weight gain (GWG), and the risk of gestational diabetes mellitus [GDM and glycated hemoglobin (HbA1c)].

Objectives

This feasibility study involved a daily probiotic intervention in obese pregnant women from the early second trimester until delivery. The primary aim was to investigate the effect on GWG and maternal glucose homeostasis (GDM and HbA1c). Secondary aims were the effect on infant birth weight, maternal gut microbiota, and other pregnancy outcomes.

Methods

We carried out a randomized double-blinded placebo-controlled study in 50 obese pregnant women. Participants were randomly allocated

SUBMITTER: Halkjær SI 

PROVIDER: S-EPMC7319727 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature