Lung metastases share common immune features regardless of primary tumor origin.

ABSTRACT:

Background

Only certain disseminated cells are able to grow in secondary organs to create a metastatic tumor. Under the hypothesis that the immune microenvironment of the host tissue may play an important role in this process, we have categorized metastatic samples based on their immune features.

Methods

Gene expression data of metastatic samples (n=374) from four secondary sites (brain, bone, liver and lung) were used to characterize samples based on their immune and stromal infiltration using gene signatures and cell quantification tools. A clustering analysis was done that separated metastatic samples into three different immune categories: high, medium and low.

Results

Significant differences were found between the immune profiles of samples metastasizing in disti

SUBMITTER: Garcia-Mulero S 

PROVIDER: S-EPMC7319789 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature