Sex as a biological variable in irritable bowel syndrome.

ABSTRACT:

Background

The pathophysiology and mechanisms of irritable bowel syndrome (IBS) involve both central and peripheral mechanisms that result in altered perception, as well as changes in bowel functions. These dysfunctions are associated with motor, sensory, immune, barrier, and intraluminal perturbations, including the microbiota, and their products and endogenous molecules with bioactive properties. There is evidence that these mechanisms are altered in both females and males. However, there is also increasing evidence that sex is a biological variable that impacts a number of aspects of the mechanisms, epidemiology, and manifestations of IBS.

Purpose

The objective of this article is to review the evidence of the differences among genders of the following factors in IBS: the

SUBMITTER: Camilleri M 

PROVIDER: S-EPMC7319890 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature