A metabolic pathway for bile acid dehydroxylation by the gut microbiome.

ABSTRACT: The gut microbiota synthesize hundreds of molecules, many of which influence host physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around 500 μM and are known to block the growth of Clostridium difficile¹, promote hepatocellular carcinoma² and modulate host metabolism via the G-protein-coupled receptor TGR5 (ref. ³). More broadly, DCA, LCA and their derivatives are major components of the recirculating pool of bile acids⁴; the size and composition of this pool are a target of therapies for primary biliary cholangitis and nonalcoholic steatohepatitis. Nonetheless, despite the clear impact of DCA and LCA on host physiology, an incomp

SUBMITTER: Funabashi M 

PROVIDER: S-EPMC7319900 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature