Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies.

ABSTRACT: Genome-wide association studies have led to a significant progress in identification of genomic loci affecting coronary artery disease (CAD) risk. However, revealing the causal genes responsible for the observed associations is challenging. In the present study, we aimed to prioritize CAD-relevant genes based on cumulative evidence from the published studies and our own study of colocalization between eQTLs and loci associated with CAD using SMR/HEIDI approach. Prior knowledge of candidate genes was extracted from both experimental and in silico studies, employing different prioritization algorithms. Our review systematized information for a total of 51 CAD-associated loci. We pinpointed 37 genes in 36 loci. For 27 genes we infer they are causal for CAD, and for 10 further genes we judge t

SUBMITTER: Shadrina AS 

PROVIDER: S-EPMC7320185 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature