Lipopolysaccharide-Induced Inflammatory Cytokine Expression in Taste Organoids.

ABSTRACT: Inflammatory cytokines are signaling molecules that regulate numerous physiological processes, from tissue homeostasis to metabolism and food intake. Expression of certain cytokines can be markedly induced in subsets of taste bud cells under acute and chronic inflammation. This may contribute to altered taste perception and preference associated with many diseases. Although the pathways of cytokine induction are well studied in immune cells, they remain poorly characterized in taste cells, in part due to the difficulties of performing biochemical analyses with a limited number of taste cells. The recently developed taste organoid model provides an opportunity to carry out these mechanistic studies in vitro. However, it was unknown whether taste organoids respond to inflammatory stimuli as

SUBMITTER: Feng S 

PROVIDER: S-EPMC7320225 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature